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SF3B1 mutations induce R-loop accumulation and DNA damage in MDS and leukemia cells with therapeutic implications.

Shalini SinghDoaa AhmedHamid DolatshadDharamveer TatwavediUlrike SchulzeAndrea SanchiSarah RyleyAshish DhirLee CarpenterSuzanne M WattDavid J RobertsAmal M Abdel-AalSohair K SayedSomaia A MohamedAnna SchuhParesh VyasSally KillickAndriana G KotiniEirini P PapapetrouDaniel H WisemanAndrea PellagattiJacqueline Boultwood
Published in: Leukemia (2020)
Keyphrases
  • dna damage
  • induced apoptosis
  • oxidative stress
  • cell cycle arrest
  • acute myeloid leukemia
  • bone marrow
  • dna repair
  • transcription factor
  • endoplasmic reticulum stress
  • signaling pathway
  • pi k akt