Establishment of patient-derived organoid models of lower grade glioma.
Kalil G AbdullahCylaina E BirdJoseph D BuehlerLauren C GattieMilan R SavaniAlex C SternishaYi XiaoMichael M LevittWilliam H HicksWenhao LiDenise M O RamirezToral PatelTomas Garzon-MuvdiSamuel BarnettGao ZhangDavid M AshleyKimmo J HatanpaaTimothy E RichardsonSamuel K McBrayerPublished in: Neuro-oncology (2021)
We report an efficient method for producing faithful in vitro models of LGG. New experimental platforms generated through this approach are well positioned to support preclinical studies of this disease, particularly those related to tumor immunology, tumor-stroma interactions, identification of novel drug targets, and personalized assessments of treatment response profiles.