Evaluation of obstetric outcomes and prognostic significance of graft function in kidney transplant recipient pregnancies.
Riza MadazlıDidem KaymakVerda AlpayHakan ErenelMevlut Tamer DincerNurhan SeyahiPublished in: Hypertension in pregnancy (2020)
Objective: To evaluate obstetric and kidney outcomes in pregnancies with kidney transplantation.Methods: We retrospectively reviewed 32 singleton pregnancies in kidney transplant recipients. Obstetric outcomes were explored according to the estimated glomerular filtration rates (eGFR) of patients.Results: The incidences of fetal growth restriction, preeclampsia were 18.8% and 34.4%, respectively. There was a significant negative correlation between first-trimester eGFR and perinatal mortality (r = -0.546, p = .0.001) and composite adverse obstetric outcome (r = -0.415, p = .0.018).Conclusion: The degree of transplanted kidney function impairment at the beginning of pregnancy is the major determinant of pregnancy outcome.
Keyphrases
- preterm birth
- pregnant women
- pregnancy outcomes
- kidney transplantation
- gestational age
- small cell lung cancer
- end stage renal disease
- epidermal growth factor receptor
- tyrosine kinase
- ejection fraction
- newly diagnosed
- chronic kidney disease
- emergency department
- early onset
- cardiovascular disease
- risk factors
- body mass index
- cardiovascular events
- patient reported outcomes
- physical activity
- insulin resistance
- weight loss
- adipose tissue
- adverse drug
- weight gain
- electronic health record