Blocking glycine receptors reduces neuroinflammation and restores neurotransmission in cerebellum through ADAM17-TNFR1-NF-κβ pathway.

Yaiza M ArenasAndrea Cabrera-PastorNora JuciuteEloy Mora-NavarroVicente Felipo

Published in: Journal of neuroinflammation (2020)

Glycinergic neurotransmission modulates neuroinflammation. Enhanced glycinergic neurotransmission in hyperammonemia would be due to reduced extracellular cGMP. These results shed some light on possible new therapeutic target pathways for pathologies associated to neuroinflammation.

Keyphrases

lps induced
lipopolysaccharide induced
traumatic brain injury
inflammatory response
cognitive impairment
cerebral ischemia
signaling pathway
nitric oxide
oxidative stress
immune response
toll like receptor
pi k akt
protein kinase