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Association of a calcium channel blocker and diuretic prescribing cascade with adverse events: A population-based cohort study.

Paula A RochonPeter C AustinSharon-Lise NormandRachel D SavageStephanie H ReadLisa M McCarthyVasily GiannakeasWei WuRachel StraussXuesong WangSimon ChenJerry H Gurwitz
Published in: Journal of the American Geriatrics Society (2023)
The CCB-diuretic prescribing cascade was associated with an increased rate of SAEs, suggesting harm beyond prescribing a second drug therapy. Our study raises awareness of the downstream impact of the CCB-diuretic prescribing cascade at a population level and provides an opportunity for clinicians who identify this prescribing cascade to review their patients' medications to determine if they can be optimized.
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