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Adipose stromal cells promote the transition of colorectal cancer cells toward a mesenchymal-like phenotype.

Simone Di FrancoGiorgio Stassi
Published in: Molecular & cellular oncology (2021)
Colon cancer progression is among the risks that increase with obesity. We have recently unveiled the molecular mechanism by which adipose tissue-released molecules, HGF and IL-6, make colorectal cancer (CRC) cells acquiring mesenchymal traits. Targeting of adipose-derived factors abrogate the metastatic potential of CRC stem cells (CR-CSCs) in obese patients.
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