Adipose stromal cells promote the transition of colorectal cancer cells toward a mesenchymal-like phenotype.
Simone Di FrancoGiorgio StassiPublished in: Molecular & cellular oncology (2021)
Colon cancer progression is among the risks that increase with obesity. We have recently unveiled the molecular mechanism by which adipose tissue-released molecules, HGF and IL-6, make colorectal cancer (CRC) cells acquiring mesenchymal traits. Targeting of adipose-derived factors abrogate the metastatic potential of CRC stem cells (CR-CSCs) in obese patients.
Keyphrases
- stem cells
- obese patients
- adipose tissue
- insulin resistance
- bariatric surgery
- weight loss
- induced apoptosis
- roux en y gastric bypass
- bone marrow
- gastric bypass
- human health
- metabolic syndrome
- high fat diet
- cell cycle arrest
- small cell lung cancer
- type diabetes
- squamous cell carcinoma
- high fat diet induced
- cell therapy
- cancer therapy
- skeletal muscle
- risk assessment
- genome wide
- gene expression
- weight gain
- climate change
- dna methylation
- signaling pathway
- pi k akt
- body mass index
- physical activity