Cannabidiol prevents chemotherapy-induced neuropathic pain by modulating spinal TLR4 via endocannabinoid system activation.

Rafaela Dos SantosFlávio VerasGonçalves NettoLívia EliseiCarlos SorgiLúcia FaccioliGiovane Galdino de-Souza

Published in: The Journal of pharmacy and pharmacology (2023)

CBD was efficient in preventing PTX-induced neuropathic pain, and this effect may involve inhibition of the TLR4 on microglia spinal with activation of the endocannabinoid system.

Keyphrases

neuropathic pain
spinal cord
spinal cord injury
chemotherapy induced
toll like receptor
inflammatory response
immune response
high glucose
diabetic rats
nuclear factor
oxidative stress
mouse model
endothelial cells
stress induced