Concordance of cerebrospinal fluid real-time quaking-induced conversion across the European Creutzfeldt-Jakob Disease Surveillance Network.
Neil McKenzieGabriele PiconiAudrey CuleuxAnna-Lena HammarinChristos StergiouSocrates TzartosAlexandra A M VersleijenJacqueline van de GeerPatrick CrasFranco CardoneAnna LadoganaAngela MannanaMarcello RossiMatilde BongianniDaniela PerraGuenther RegelsbergerSigrid KlotzSimone HornemannAdriano AguzziMatthias SchmitzMary AndrewsKimberley BurnsStéphane HaïkRaquel Ruiz-GarcíaJenny Verner-CarlssonJohn TzartosMarcel M VerbeekBart De VilAnna PoleggiPiero ParchiGianluigi ZanussoEllen GelpiKarl FrontzekRegina ReimannPeter HermannInga ZerrSuvankar PalAlison J E GreenPublished in: European journal of neurology (2022)
This study shows that CSF RT-QuIC demonstrates an excellent concordance between centres, even when using a variety of instrumentation, recombinant prion protein substrates and CSF volumes. The adoption of CSF RT-QuIC by all CJD surveillance centres is recommended.