Integrative analysis of competitive endogenous RNA network reveals the regulatory role of non-coding RNAs in high-glucose-induced human retinal endothelial cells.

Nan-Jue Cao He-Nan LiuFeng DongWei Wang Wei SunGang Wang

Published in: PeerJ (2020)

We successfully built the key ceRNA subnetwork, OIP5-AS1/miR-449c/MYC, by applying the GEO database for data analysis and mining. The results from the ceRNA network allow us to better understand the effect of ncRNAs on HRECs under hyperglycemic conditions and the pathogenesis of DR.

Keyphrases

high glucose
endothelial cells
data analysis
long non coding rna
cell proliferation
vascular endothelial growth factor
optical coherence tomography
network analysis
diabetic retinopathy
long noncoding rna
adverse drug
optic nerve
nucleic acid
drug induced