Targeting ferroptosis alleviates methionine-choline deficient (MCD)-diet induced NASH by suppressing liver lipotoxicity.

Xiaoya LiTian-Xiang WangXinmei HuangYue LiTiange SunShufei ZangKun-Liang GuanYue XiongJun LiuHai-Xin Yuan

Published in: Liver international : official journal of the International Association for the Study of the Liver (2020)

Our results demonstrate an important role of ferroptosis in the progression of MCD-diet induced NASH and suggest that ferroptosis may serve as a therapeutic target for NASH treatment.

Keyphrases

cell death
drug delivery
replacement therapy