Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer.
Nadia BoufaiedPaolo ChettaTarek HallalStefano CacciatoreDaniela LalliCarole LutholdKevin HomsyEddie Luidy ImadaSudeepa SyamalaCornelia PhotopoulosAnna Di MatteoAnna de PoloAlessandra Maria StoraciYing HuangFrancesca GiunchiPatricia A SheridanGregory A MichelottiQuang-De NguyenXin ZhaoYang LiuElai DavicioniDaniel E SprattSimone SabbionedaGiovanni MagaLorelei A MucciClaudia GhignaLuigi MarchionniLisa M ButlerLeigh EllisFrancois BordeleauMassimo LodaValentina VairaDavid P LabbéGiorgia ZadraPublished in: Cancer research (2024)
Lactate accumulation driven by high-fat diet and MYC reprograms the tumor microenvironment and promotes prostate cancer progression, supporting the potential of lactate as a biomarker and therapeutic target in prostate cancer. See related commentary by Frigo, p. 1742.