Prokinetic actions of luminally acting 5-HT4 receptor agonists.
John R KonenMelody M HaagDaria GusevaMolly HurdAlisha A LintonBrigitte LavoieColleen B KerriganEmily JoyceStephan C BischoffSteve SwannLuana GriffinJun MatsukawaMatthew D FalkTony S GibsonGrant W HennigJill WykoskyGary M MawePublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2020)
These findings demonstrated that stimulation of epithelial 5-HT4 Rs can potentiate propulsive motility and support the concept that mucosal 5-HT4 Rs could represent a safe and effective therapeutic target for the treatment of constipation.