Zinc-finger E-box-binding homeobox 1 (ZEB1) plays a crucial role in the maintenance of lung cancer stem cells resistant to gefitinib.

Fariz NurwidyaFumiyuki TakahashiWira WinardiKen TajimaYoichiro MitsuishiAkiko MurakamiIsao KobayashiTakeshi NaraMuneaki HashimotoMotoyasu KatoMoulid HidayatKentaro SuinaDaisuke HayakawaTetsuhiko AsaoRyo Ko Takehito ShukuyaToshifumi YaeNaoko ShimadaYasuko YoshiokaShinichi SasakiKazuhisa Takahashi

Published in: Thoracic cancer (2021)

ZEB1 plays an important role in gefitinib-resistant lung CSCs with EMT features via regulation of miR-200c and BMI1.

Keyphrases

cancer stem cells
epithelial mesenchymal transition
long non coding rna
small cell lung cancer
cell proliferation
epidermal growth factor receptor
binding protein
transcription factor
signaling pathway