Chromoplexy Is a Frequent Early Clonal Event in EWSR1-Rearranged Round Cell Sarcomas That Can Be Detected Using Clinically Validated Targeted Sequencing Panels.
Josephine Kam Tai K DermawanEmily K SlotkinWilliam D TapPaul A MeyersLeonard H WexlerJohn H HealeyFabio VanoliChad M VanderbiltCristina R AntonescuPublished in: Cancer research (2024)
Chromoplexy is detectable using targeted NGS in a substantial portion of EWSR1-rearranged round cell sarcomas as an early and persistent clonal event, expanding the genomic complexity of fusion-associated sarcomas.