Chronic viral infections impinge on naive bystander CD8 T cells.
Isabel BarnstorfSuzanne P M WeltenMariana BorsaNicolas S BaumannKatharina PallmerNicole JollerRoman SpörriAnnette OxeniusPublished in: Immunity, inflammation and disease (2020)
Our results document numeric, phenotypic, and functional adaptation of bystander naive CD8 T cells during nonrelated chronic viral infection. Their functional impairment was only evident in the chronically infected host, indicating that T-cell extrinsic factors, in particular the quality of priming APCs, are responsible for the impaired function of naive bystander T cells in the chronically infected hosts.