A novel IFNα-induced long noncoding RNA negatively regulates immunosuppression by interrupting H3K27 acetylation in head and neck squamous cell carcinoma.

Hai-Long MaHanyue ChangWenyi YangYusheng LuJingzhou HuShufang Jin

Published in: Molecular cancer (2020)

Our results suggest that lncMX1-215 negatively regulates immunosuppression by interrupting GCN5/H3K27ac binding in HNSCC, thus providing novel insights into immune checkpoint blockade treatment.

Keyphrases

long noncoding rna
immune response
high glucose
diabetic rats
dendritic cells
drug induced
dna binding
endothelial cells
histone deacetylase
smoking cessation