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Mutant NRAS Q61K is responsible for MAPK pathway activation in the MARIMO cell line and renders these cells independent of the CALR-MPL-JAK2-STAT5 pathway.

Lijuan HanJulia CzechAngela MaurerTim H BrümmendorfNicolas ChatainSteffen Koschmieder
Published in: Leukemia (2018)
Keyphrases
  • induced apoptosis
  • signaling pathway
  • wild type
  • cell cycle arrest
  • oxidative stress