TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation.
Miguel MoutinhoIsrael CoronelAndy P TsaiGonzalo Viana Di PriscoTaylor PenningtonBrady K AtwoodShweta S PuntambekarDaniel C SmithPablo MartinezSeonggyun HanYounghee LeeCristian A Lasagna-ReevesBruce T LambStephanie J BisselKwangsik NhoGary E LandrethPublished in: Genome medicine (2023)
TREM2 transcripts can give rise to a heterogeneous pool of sTREM2 which acts to inhibit LTP. These results provide novel insight into the generation, regulation, and function of sTREM2 which fits into the complex biology of TREM2 and its role in human health and disease. Given that sTREM2 levels are linked to AD pathogenesis and progression, our finding that sTREM2 species interfere with LTP furthers our understanding about the role of TREM2 in AD.