Epigenetic suppression of FBXL7 promotes metastasis.

Published in: Molecular & cellular oncology (2020)

Epigenetic reprogramming is emerging as a key mechanism for metastasis development. Our study identified a novel regulatory mechanism whereby promoter methylation-mediated epigenetic silencing of the gene encoding the ubiquitin ligase subunit F-box/LRR-repeat protein 7 (FBXL7) induces accumulation of active c-SRC, which, in turn, activates epithelial-to-mesenchymal transition and supports cancer cell invasion and metastasis.

Keyphrases

dna methylation
gene expression
genome wide
transcription factor
copy number
binding protein
papillary thyroid
tyrosine kinase
squamous cell carcinoma
small molecule
young adults
genome wide identification