Hydrogen sulfide inhibits alveolar type II cell senescence and limits pulmonary fibrosis via promoting MDM2-mediated p53 degradation.

Xiu-Li WangYi-Tong XuShu-Li ZhangXiao-Yan ZhuHong-Xia ZhangYu-Jian Liu

Published in: Acta physiologica (Oxford, England) (2023)

S synthesis may contribute to the development of pulmonary fibrosis through promoting the activation loop involving senescent AT2 cells and activated fibroblasts.

Keyphrases

pulmonary fibrosis
induced apoptosis
cell cycle arrest
cell therapy
dna damage
endothelial cells
transcription factor
endoplasmic reticulum stress
stem cells
signaling pathway
extracellular matrix
oxidative stress
stress induced