Metabolism and pharmacokinetics characterization of metarrestin in multiple species.

Elias C PadilhaPranav ShahAmy Q WangMarc D SingletonEmma A HughesDandan LiKelly A RiceKylie M KonrathSamarjit PatnaikJuan MaruganRushikesh SableXin Xu

Published in: Cancer chemotherapy and pharmacology (2020)

Metarrestin is a low clearance compound which has good bioavailability and large biodistribution after oral administration. Biotransformation appears to be the major elimination process for the parent drug. In vitro data suggest a low drug-drug interaction potential on CYP-mediated metabolism. Overall favorable ADME and PK properties support metarrestin's progression to clinical investigation.

Keyphrases

adverse drug
molecular docking
computed tomography
big data
risk assessment
deep learning
climate change
human health