Success and limitations of plasma treatment in pregnant women with congenital thrombotic thrombocytopenic purpura.

Kazuya SakaiYoshihiro FujimuraYasuyuki NagataSatoshi HigasaMasato MoriyamaAyami IsonishiMutsuko KonnoMichiko KajiwaraYoshiyuki OgawaShigehiko KaburagiTomoko HaraKoichi KokameToshiyuki MiyataKinta HatakeyamaMasanori Matsumoto

Published in: Journal of thrombosis and haemostasis : JTH (2020)

Our results indicate that FFP infusions of more than 5 mL/kg/wk should be initiated as soon as patients become pregnant. However, even with these infusions, patients with repeated TTP episodes before pregnancy might have difficulty giving birth successfully. Recombinant ADAMTS13 products might be new treatment options for pregnant patients with cTTP.

Keyphrases

pregnant women
pregnancy outcomes
end stage renal disease
newly diagnosed
ejection fraction
prognostic factors
peritoneal dialysis
patient reported outcomes
combination therapy