MTHFR 677T-1298C haplotype in acute lymphoblastic leukemia: Impact on methotrexate therapy.

Rim FrikhaMoez ElloumiTarek RebaiHassen Kamoun

Published in: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners (2021)

Despite the limitation of this study; our results suggest that the MTHFR 677T-1298C haplotype is common in ALL and may be a promising HD-MTX chemotherapy-related adverse effects biomarker.

Keyphrases

acute lymphoblastic leukemia
high dose
allogeneic hematopoietic stem cell transplantation
radiation therapy
low dose
drug induced
smoking cessation