ST8SIA1 inhibition sensitizes triple negative breast cancer to chemotherapy via suppressing Wnt/β-catenin and FAK/Akt/mTOR.

H Wan Z Li H Wang F Cai Lin Wang

Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2020)

These findings provide an explanation for the heterogeneity of chemotherapy responses across TNBC individuals and reveal the supportive roles of ST8SIA1in TNBC chemoresistance.

Keyphrases

cell proliferation
signaling pathway
locally advanced
single cell
stem cells
epithelial mesenchymal transition
genome wide
squamous cell carcinoma
chemotherapy induced
rectal cancer
cancer stem cells