Simultaneously Enhanced Singlet Oxygen and Fluorescence Production of Nanoplatform by Surface Plasmon Resonance Coupling for Biomedical Applications.

Photodynamic therapy (PDT) and fluorescence imaging offer the possibility of precise and personalized treatment of cancer, but low singlet oxygen production of a commercial photosensitizer and the quenching effect of fluorescent dyes limit the further application of PDT treatment and fluorescence imaging. In addition, the single nanoplatform that simultaneously achieved singlet oxygen and fluorescence enhancement is rare. In this paper, a novel simultaneously enhanced singlet oxygen and fluorescence production nanoplatform of AuNR@mSiO2-Ce6-Cy5.5 has been successfully designed and synthesized by surface plasmon resonance coupling. The as-synthesized nanoplatform achieved a 1.8-fold enhancement of the singlet oxygen production of Ce6 and a 5.0-fold enhancement of the fluorescence production of Cy5.5 by surface plasmon resonance coupling. The as-synthesized nanoplatform simultaneously enhances the photodynamic therapy and fluorescence imaging of cancer, which will have great potential in biomedical applications.