Serum metabolites detect the presence of advanced fibrosis in derivation and validation cohorts of patients with non-alcoholic fatty liver disease.
Cyrielle CaussyVeeral H AjmeraPuneet PuriCynthia Li-Shin HsuShirin BassirianMania MgdsyanSeema SinghClaire FaulknerMark A ValasekEmily RizoLisa RichardsDavid A BrennerClaude B SirlinArun J SanyalRohit LoombaPublished in: Gut (2018)
A combination of 10 serum metabolites demonstrated excellent discriminatory ability for the detection of advanced fibrosis in an derivation and two independent validation cohorts with greater diagnostic accuracy than the FIB-4-index and NFS. This proof-of-concept study demonstrates that a non-invasive blood-based diagnostic test can provide excellent performance characteristics for the detection of advanced fibrosis.