Glycobiology of Cancer: Sugar Drives the Show.

Jhenifer Santos Dos ReisMarcos André Rodrigues da Costa SantosDaniella Pereira MendonçaStefani Ingrid Martins do NascimentoPedro Marçal BarcelosRafaela Gomes Correia de LimaKelli Monteiro da CostaCelio Geraldo Freire-de-LimaAlexandre MorrotJose Osvaldo PreviatoLucia Mendonça PreviatoLeonardo Marques da FonsecaLeonardo Freire-de-Lima

Published in: Medicines (Basel, Switzerland) (2022)

Cancer development and progression is associated with aberrant changes in cellular glycosylation. Cells expressing altered glycan-structures are recognized by cells of the immune system, favoring the induction of inhibitory immune processes which subsequently promote tumor growth and spreading. Here, we discuss about the importance of glycobiology in modern medicine, taking into account the impact of altered glycan structures expressed in cancer cells as potential glycobiomarkers of disease, as well as on cancer development and progression.

Keyphrases

papillary thyroid
induced apoptosis
squamous cell
cell cycle arrest
young adults
childhood cancer
risk assessment
endoplasmic reticulum stress