Chromosome 9p copy number gains involving PD-L1 are associated with a specific proliferation and immune-modulating gene expression program active across major cancer types.
Jan BudcziesCarsten DenkertBalázs GyőrffyPeter SchirmacherAlbrecht StenzingerPublished in: BMC medical genomics (2017)
Collectively, these data shed light on mechanisms of immune escape and stimulation of proliferation in cancer with PD-L1 CNG and highlight additional vulnerabilities that may be therapeutically exploitable.