Effects of gene-lifestyle interactions on obesity based on a multi-locus risk score: A cross-sectional analysis.

Sho NakamuraXuemin FangYoshinobu SaitoHiroto NarimatsuAzusa OtaHiroaki IkezakiChisato ShimanoeKeitaro TanakaYoko KuboMineko TsukamotoTakashi TamuraAsahi HishidaIsao OzeYuriko N KoyanagiYohko NakamuraMiho KusakabeToshiro TakezakiDaisaku NishimotoSadao SuzukiTakahiro OtaniNagato KuriyamaDaisuke MatsuiKiyonori KurikiAya KadotaYasuyuki NakamuraKokichi ArisawaSakurako Katsuura-KamanoMasahiro NakatochiYukihide MomozawaMichiaki KuboKenji TakeuchiKenji Wakai

Published in: PloS one (2023)

Our results provide evidence of an interaction effect between GRS and nutritional intake and physical activity. This gene-lifestyle interaction provides a basis for developing prevention or treatment interventions for obesity according to individual genetic predisposition.

Keyphrases

physical activity
weight loss
metabolic syndrome
genome wide
copy number
insulin resistance
weight gain
type diabetes
high fat diet induced
cardiovascular disease
dna methylation
adipose tissue
sleep quality
combination therapy
skeletal muscle
smoking cessation