Anti-inflammatory, antioxidant and renoprotective effects of SOCS1 mimetic peptide in the BTBR ob/ob mouse model of type 2 diabetes.

Lucas Opazo-RiosYenniffer Sanchez MatusRaúl R Rodrigues-DíezDaniel CarpioAlejandra DroguettJesús EgidoCarmen Gomez-GuerreroSergio Mezzano

Published in: BMJ open diabetes research & care (2021)

Targeting SOCS proteins by mimetic peptides to control JAK/STAT signaling pathway ameliorates albuminuria, morphological renal lesions, inflammation, oxidative stress and lipotoxicity, and could be a therapeutic approach to T2D kidney disease.

Keyphrases

oxidative stress
mouse model
anti inflammatory
signaling pathway
induced apoptosis
ischemia reperfusion injury
diabetic rats
dna damage
pi k akt
cancer therapy
amino acid
cell proliferation
heat stress