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Spindle cell neoplasms with novel LTK fusion - Expanding the spectrum of kinase fusion-positive soft tissue tumors.

Maximus C F YeungJosephine K DermawanAnthony P Y LiuAlbert Y L LamCristina R AntonescuTony W H Shek
Published in: Genes, chromosomes & cancer (2024)
This is the first reported case series of soft tissue tumors harboring LTK fusion, expanding the molecular landscape of soft tissue tumors driven by activating kinase fusions. Furthermore, studies involving a larger number of cases and integrated genomic analyses will be warranted to fully elucidate the pathogenesis and classification of these tumors.
Keyphrases
  • soft tissue
  • single cell
  • machine learning
  • signaling pathway
  • protein kinase
  • deep learning
  • gene expression
  • copy number
  • stem cells
  • dna methylation
  • mesenchymal stem cells