DNA Methylation of the Natriuretic Peptide System Genes and Ischemic Stroke: Gene-Based and Gene Set Analyses.

Hao PengYiming FanJing LiXiaowei ZhengChongke ZhongZhengbao ZhuYan HeMingzhi ZhangYonghong Zhang

Published in: Neurology. Genetics (2022)

DNA methylation at NP system genes was downregulated in patients with IS. Our results may unravel a molecular mechanism underlying the regulating effect of the NP system on IS and highlight the relevance of testing the joint effect of multiple CpGs in the epigenetic analysis.

Keyphrases

genome wide
dna methylation
genome wide identification
copy number
gene expression
genome wide analysis
transcription factor
atrial fibrillation