Mitochondrial dysfunction mediated through dynamin-related protein 1 (Drp1) propagates impairment in blood brain barrier in septic encephalopathy.

Bereketeab HaileselassieAmit U JoshiParas S MinhasRiddhita MukherjeeKatrin I AndreassonDaria Mochly-Rosen

Published in: Journal of neuroinflammation (2020)

LPS-induced impairment of BBB appears to be dependent on Drp1-Fis1-mediated mitochondrial dysfunction. Inhibition of mitochondrial dysfunction with P110 may have potential therapeutic significance in septic encephalopathy.

Keyphrases

blood brain barrier
lps induced
inflammatory response
acute kidney injury
early onset
cerebral ischemia