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Perspective: the essential role of NMR in the discovery and characterization of intrinsically disordered proteins.

H Jane DysonPeter E Wright
Published in: Journal of biomolecular NMR (2019)
The 2019 ISMAR Prize recognized NMR studies of disordered proteins. Here we provide a highly personal perspective on the discovery of intrinsically disordered proteins and the development and application of NMR methods to characterize their conformational ensembles, dynamics, and interactions.
Keyphrases
  • magnetic resonance
  • high resolution
  • solid state
  • small molecule
  • high throughput
  • molecular dynamics