The mediation role of SOCS3 methylation in the effect of serum testosterone on type 2 diabetes.

Lulu WangXiaotiao LiuDandan WeiNing KangLuting NiePengling LiuKeliang FanLi ZhangJian HouXing LiShunqing XuTao JingWenjie LiChongjian Wang Zhenxing Mao Wenqian Huo

Published in: Journal of diabetes (2021)

High levels of serum testosterone in men and Chr17:76356190 and Chr17:76356199 (SOCS3) methylation were related to a lower prevalent T2D. In addition, Chr17:76356190 methylation partially mediated the effect of testosterone on T2D in Chinese rural men.

Keyphrases

replacement therapy
type diabetes
genome wide
dna methylation
middle aged
south africa
cardiovascular disease
glycemic control
insulin resistance
depressive symptoms
metabolic syndrome
weight loss