Cardiac repolarization during fingolimod treatment in patients with relapsing-remitting multiple sclerosis.

Aapo LaihoTiina M LaitinenPäivi HartikainenJuha E K HartikainenTomi P LaitinenSakari Simula

Published in: Brain and behavior (2018)

Changes in cardiac repolarization after fingolimod initiation were mild and occurred at daytime. Ambiguously, QTcBaz demonstrated shortening, whereas QTcFri showed prolongation in cardiac repolarization after fingolimod initiation. The formula applied for QT-interval correction needs to be taken carefully into account as evaluating pharmacovigilance issues related to fingolimod.

Keyphrases

multiple sclerosis
white matter
left ventricular
drug induced
obstructive sleep apnea
rheumatoid arthritis
sleep quality
heart failure
emergency department
physical activity
adverse drug
human milk
electronic health record