Non‑small cell lung cancer (NSCLC) is a highly prevalent lung malignancy characterized by insidious onset, rapid progression and advanced stage at the time of diagnosis, making radical surgery impossible. Sirtuin (SIRT) is a histone deacetylase that relies on NAD+ for its function, regulating the aging process through modifications in protein activity and stability. It is intricately linked to various processes, including glycolipid metabolism, inflammation, lifespan regulation, tumor formation and stress response. An increasing number of studies indicate that SIRTs significantly contribute to the progression of NSCLC by regulating pathophysiological processes such as energy metabolism, autophagy and apoptosis in tumor cells through the deacetylation of histones or non‑histone proteins. The present review elaborates on the roles of different SIRTs and their mechanisms in NSCLC, while also summarizing novel therapeutic agents based on SIRTs. It aims to present new ideas and a theoretical basis for NSCLC treatment.
Keyphrases
- small cell lung cancer
- oxidative stress
- advanced non small cell lung cancer
- histone deacetylase
- endoplasmic reticulum stress
- cell death
- brain metastases
- minimally invasive
- dna methylation
- coronary artery bypass
- gene expression
- cell cycle arrest
- coronary artery disease
- cell proliferation
- binding protein
- protein protein
- sensitive detection
- percutaneous coronary intervention
- replacement therapy