Epigenetic priming sensitizes gastric cancer cells to irinotecan and cisplatin by restoring multiple pathways.

Hiroshi MoroNaoko HattoriYoshiaki NakamuraKana KimuraToshio ImaiMasahiro MaedaMasakazu YashiroToshikazu Ushijima

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2019)

Epigenetic priming with 5-aza-dC can improve the sensitivity of gastric cancer cells to SN38 and CDDP.

Keyphrases

dna methylation
gene expression
dendritic cells
induced apoptosis
immune response
signaling pathway