Technical feasibility of [18F]FET and [18F]FAZA PET guided radiotherapy in a F98 glioblastoma rat model.

Jeroen VerhoevenJulie BolcaenValerie De MeulenaereKen KersemansBenedicte DescampsSam DoncheCaroline Van den BroeckeTom BoterbergJean-Pierre KalalaKarel DeblaereChristian VanhoveFilip De VosIngeborg Goethals

Published in: Radiation oncology (London, England) (2019)

In this study we showed the feasibility of PET guided subvolume boosting of F98 glioblastoma in rats. No evidence was found for a beneficial effect regarding tumor response. However, improvements for dose targeting in rodents and studies investigating new targeted drugs for GB treatment are mandatory.

Keyphrases

pet ct
cancer therapy
computed tomography
positron emission tomography
early stage
pet imaging
radiation therapy
radiation induced
locally advanced
drug delivery
squamous cell carcinoma
case control
replacement therapy
rectal cancer