Theabrownin Induces Apoptosis and Tumor Inhibition of Hepatocellular Carcinoma Huh7 Cells Through ASK1-JNK-c-Jun Pathway.

Jiaan XuBo YanLei ZhangLi ZhouJin ZhangWenhua YuXiaoqiao DongLi Yao Le-Tian Shan

Published in: OncoTargets and therapy (2020)

TB exerts anti-proliferative, pro-apoptotic, and tumor-inhibitory effects on Huh7 cells through activation of the JNK signaling pathway. For the first time, this study provides new evidence of anti-HCC effects and mechanism of TB.

Keyphrases

induced apoptosis
signaling pathway
cell death
cell cycle arrest
endoplasmic reticulum stress
pi k akt
oxidative stress
epithelial mesenchymal transition