Hepatic exposure of metformin in patients with non-alcoholic fatty liver disease.
Elias Immanuel Ordell SundelinLars Christian GormsenSara HeebøllMikkel Holm VendelboSteen JakobsenOle Lajord MunkSøren FeddersenKim BrøsenStephen Jacques Hamilton-DutoitSteen Bønløkke PedersenHenning GrønbaekNiels JessenPublished in: British journal of clinical pharmacology (2019)
Metformin is distributed to the liver in patients with NAFLD and the distribution is not impaired by inflammation or fibrosis. The findings imply that metformin action in liver in patients with NAFLD may be preserved.
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