Association between low fetal fraction in cell-free DNA testing and adverse pregnancy outcome: A systematic review.

Peter G SchefferSoetinah A M WirjosoekartoEllis C BeckingMarjan M WeissCaroline J BaxDick OepkesErik A SistermansLidewij Henneman Mirielle N Bekker

Published in: Prenatal diagnosis (2021)

LFF in cfDNA testing is associated with adverse pregnancy outcome,specifically pregnancy-related hypertensive disorders, preterm birth, and impaired fetal growth related to placental dysfunction. Since the available evidence is limited, a large prospective cohort study on the relationship between fetal fraction and pregnancy outcomes is needed.

Keyphrases

preterm birth
pregnancy outcomes
low birth weight
pregnant women
gestational age
blood pressure
oxidative stress
emergency department
adverse drug