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Causal associations of physical activity and leisure sedentary behaviors with age at onset of Huntington's disease: A mendelian randomization study.

Haonan WangYinghong DaiYihong TaiZeng ZhouXin ZhouBin LiLiang Yu
Published in: Parkinsonism & related disorders (2024)
The study revealed a unidirectional causality between PA, LSB and the AAO of HD. Increasing PA and reducing TV time delay HD onset. Therefore, we recommend increasing physical activity and reducing sedentary behavior to delay the occurrence of motor symptoms for premanifest HD individuals.
Keyphrases
  • physical activity
  • body mass index
  • risk assessment
  • emergency department
  • single cell