Clinical Characteristics and Mutation Analyses of Ovarian Sertoli-Leydig Cell Tumors.

Zhen YuanXiao HuoDezhi JiangMei YuDongyan CaoHuanwen WuKeng ShenJiaxin YangYing ZhangHuimei ZhouYao Wang

Published in: The oncologist (2020)

Bilateral ovarian Sertoli-Leydig cell tumors were verified to be primary tumors from the genetic perspective. The rates of germline and somatic DICER1 mutations were 4 of 17 (23.5%) and 4 of 19 (21.1%), respectively. The rates of germline and somatic DICER1 mutations were higher in patients who were younger than 18 years than those in older patients (p = .022 and p = .001, respectively).

Keyphrases

single cell
copy number
cell therapy
dna repair
stem cells
case report
mesenchymal stem cells