Protective effects of Stevia rebaudiana extracts on beta cells in lipotoxic conditions.

Marco BuglianiSilvia TavariniFrancesca GranoSilvia TondiSerena LacerenzaLaura GiustiMaurizio RonciAnna MaidecchiPiero MarchettiMarta TesiLuciana G Angelini

Published in: Acta diabetologica (2021)

Stevia rebaudiana leaf extracts have beneficial effects on beta cells exposed to lipotoxicity; this effect does not seem to be mediated by stevioside alone (suggesting a major role of the leaf phytocomplex as a whole) and might be due to actions on the endoplasmic reticulum and the mitochondrion.

Keyphrases

induced apoptosis
endoplasmic reticulum
cell cycle arrest
oxidative stress
cell death
signaling pathway
cell proliferation
pi k akt