Pioneering the Photoactive Relevance of Quinazolinone-Fullereropyrrolidine Nanohybrids To Address Chemotherapeutic Resistance in Cancer.
Devashish SenguptaDebdulal SharmaRanjan Kumar DasPrem DasMadhumanti HalderPushkar RaiOishee ChakrabartiPublished in: ACS medicinal chemistry letters (2024)
This study investigates the impact of C 70 and C 60 fullerenes on quinazolinone, specifically in quinazolinone-fulleropyrrolidine nanohybrids. The nanohybrids Q 3 C 70 M and Q 3 C 60 M exhibit distinct spectral shifts and have significant photobiological antineoplastic properties. Q 3 C 60 M enhances apoptosis, while Q 3 C 70 M reduces Cyclin A levels and counteracts oncogenic effects by promoting cell differentiation. Q 3 C 70 M demonstrates heightened cytotoxicity by overcoming chemotherapy resistance by modulating BAX and BCL-2 levels. This innovative approach, distinguishing between C 70 and C 60 , represents a novel contribution to the existing scientific literature.
Keyphrases
- reduced graphene oxide
- cell cycle arrest
- papillary thyroid
- systematic review
- oxidative stress
- cell death
- optical coherence tomography
- signaling pathway
- cell cycle
- gold nanoparticles
- squamous cell
- squamous cell carcinoma
- magnetic resonance imaging
- induced apoptosis
- radiation therapy
- young adults
- locally advanced
- magnetic resonance
- computed tomography
- childhood cancer
- lymph node metastasis