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T-Cell MyD88 Is a Novel Regulator of Cardiac Fibrosis Through Modulation of T-Cell Activation.

Abraham L BayerSasha SmolgovskyNjabulo NgwenyamaAna Hernández-MartínezKuljeet KaurKatherine SulkaJunedh M AmruteMark AronovitzKory J LavineShruti SharmaPilar Alcaide
Published in: Circulation research (2023)
Our results outline a novel intrinsic role for MyD88 in limiting T-cell activation that is central to tune down cardiac inflammation during cardiac adaptation to stress.
Keyphrases
  • left ventricular
  • toll like receptor
  • oxidative stress
  • transcription factor
  • heart failure
  • immune response
  • inflammatory response