Lung function, airway and peripheral basophils and eosinophils are associated with molecular pharmacogenomic endotypes of steroid response in severe asthma.
Alvin T KhoMichael J McGeachieJiang LiRobert P ChaseSami S AmrAnnette T HastieGregory A HawkinsXingnan LiGeoffrey L ChuppDeborah A MeyersEugene R BleeckerScott T WeissKelan G TantisiraPublished in: Thorax (2021)
Transcriptomic PCs from this unsupervised methodology define molecular pharmacogenomic endotypes that may yield novel biology underlying different subject-specific responses to corticosteroid therapy in asthma, and optimal personalised asthma care. Top contributing genes to these PCs may suggest new therapeutic targets.
Keyphrases
- lung function
- chronic obstructive pulmonary disease
- cystic fibrosis
- air pollution
- healthcare
- clinical decision support
- machine learning
- palliative care
- genome wide
- single molecule
- quality improvement
- gene expression
- pain management
- rna seq
- mesenchymal stem cells
- bone marrow
- allergic rhinitis
- affordable care act
- cell therapy
- genome wide identification