Sex-Related Differences in Loop Gain During High Altitude Sleep Disordered Breathing.
Jordan D BirdScott A SandsRaichel M AlexConan L H ShingBrooke M ShaferNicholas G JendzjowskyRichard J A WilsonTrevor A DayGlen E FosterPublished in: Annals of the American Thoracic Society (2023)
The loop gain response to high altitude differed between sexes and contributed to worsening of CSA over time in men but not women. This sex-difference in acclimatization appears to protect females from high altitude related CSA. These data provide fundamental sex-specific physiological insight into high altitude acclimatization in healthy individuals and may help to inform sex differences in sleep disordered breathing pathogenesis in patients with cardiorespiratory disease.