Prediction of future insulin-deficiency in glutamic acid decarboxylase autoantibody enzyme-linked immunosorbent assay-positive patients with slowly-progressive type 1 diabetes.
Eiji KawasakiTakuya AwataHiroshi IkegamiAkihisa ImagawaYoichi OikawaHaruhiko OsawaTakeshi KatsukiNorio KanatsunaRyoichi KawamuraJunji KozawaNoriko KodaniTetsuro KobayashiAkira ShimadaMasayuki ShimodaKazuma TakahashiDaisuke ChujoTetsuro TsujimotoKyoichiro TsuchiyaAiko TerakawaJungo TerasakiKan NagasawaShinsuke NosoTomoyasu FukuiIchiro HorieKazuki YasudaHisafumi YasudaHidekatsu YanaiToshiaki HanafusaHiroshi Kajionull nullPublished in: Journal of diabetes investigation (2024)
Our findings show that, unlike RIA-GADA, ELISA-GADA shows no association between GADA titers and the risk of progression to an insulin-dependent state. The PPV improves when age at diagnosis, BMI and F-CPR levels are considered in combination.